FIG. 2.

Study of activity of L-amphotericin at doses ranging from 1 to 50 mg/kg given four times to mice infected with strain AF65 compared with those of amphotericin B and dextrose (control). Plots are of cumulative mortality against time after AF65 infection and treatment with L-amphotericin. □, L-amphotericin at 50 mg/kg on days 1, 2, 4, and 7; ▵, L-amphotericin at 25 mg/kg on days 1, 2, 4, and 7; ⧫, L-amphotericin at 5 mg/kg on days 1, 2, 4, and 7; ◊, L-amphotericin at 1 mg/kg on days 1, 2, 4, and 7; ■, amphotericin B at 5 mg/kg on days 1, 2, 4, and 7; ×, no active treatment.