FIG. 4.

Comparison of treatment with two doses (1 and 5 mg/kg) of L-nystatin, L-amphotericin, ABLC, and amphotericin B with control treatments in a model of invasive aspergillosis caused by AF65 in temporarily neutropenic mice. For all groups except L-nystatin at 1 mg/kg and amphotericin B at 1 mg/kg, the data are from two experiments. Plots are of cumulative mortality against time after AF65 infection and various treatments. ▴, L-nystatin at 2.5 mg/kg twice daily on days 1, 2, 4, and 7; ▵, L-nystatin at 0.5 mg/kg twice daily on days 1, 2, 4, and 7; ⧫, L-amphotericin at 5 mg/kg on days 1, 2, 4, and 7; ◊, L-amphotericin at 1 mg/kg on days 1, 2, 4, and 7; ●, ABLC at 5 mg/kg on days 1 to 7; ○, ABLC at 1 mg/kg on days 1 to 7; ■, amphotericin B at 5 mg/kg on days 1, 2, 4, and 7; □, amphotericin B at 1 mg/kg on days 1, 2, 4, and 7; ×, no active treatment.