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. 2022 Mar 18;11(6):1690. doi: 10.3390/jcm11061690

Figure 1.

Figure 1

Predicted Ro52 peptide binders docked on HLA-DRB1*0103. (A,B) Based on the prediction by SMM-align (stabilization matrix alignment) using IEDB, the top two peptides with IC50 values of 28 and 29 were docked onto the crystal structure of HLA-DRB1*0103 PDB structure 1A6A, and the most optimum predicted position of docking is indicated for both peptides-NPWLILSEDRRQVRL and ANPWLILSEDRRQVR with the core sequence of LSEDRRQVR and LILSEDRRQ, respectively. (C,D) The highlighted region indicates the presence of the peptides in the three-dimensional structure of the Ro52 protein.