Table 3.

Peptides for SjS that have been tested in vivo.

Peptide	Amino Acids	Amino Acid Sequence	In Vivo Confirmation	References	HLA-DR3	IC50
M3R	205–237	LFWQYFVGKRTVPPGECFIQFLSEPTITFGTAI	NOD/LtJ mice	[59]	GECFIQFLSEPTITF	473
	208–227	QYFVGKRTVPPGECFIQFLS	Immunization of young female NOD/LtJ mice on autoimmune response	[60]	QYFVGKRTVPPGECF	8607
		Part of second extracellular loop
	213–228	KRTVPPGECFIQFLSE	BALB/c	[61]	KRTVPPGECFIQFLS	50,000
	514–527	NTFCDSCIPKTFWN	BALB/c	[61]	NTFCDSCIPKTFWNL	6549
		MTLHSNSTTSPLFPNISSSWVHSPSEAGLP, N1	C57BL/6j (B6) mice (M3R+/+) M3R−/− mice Rag1−/− mice	[62]	PNISSSWVHSPSEAG	4760
		VHSPSEAGLPLGTVSQLDSYNISGTSGNFS, N2			LPLGTVSQLDSYNIS	6028
		NISQTSGNFSSNDTSSDPLGGHTIWQV, N3			TSGNFSSNDTSSDPL	6471
		FTTYIIMNRWALGNLACDLW, Extracellular loop 1			FTTYIIMNRWALGNL	955
		QYFVGKRTVPPGECFIQFLSEP, Extracellular loop 2			QYFVGKRTVPPGECF	8607
		VLVNTFCDSCIPKTYWNLGY, Extracellular loop 3			VLVNTFCDSCIPKTY	5219
	H 441–465	PAGGTDCSLPMIWAQKTNTPADVFI	SJL/L (H-2s) A/J(H-2a)	[63]	TDCSLPMIWAQKTNT	2068
	H 316–335	KARIHPFHILIALETYKTGH	SJL/L (H-2s) BALB/c (H-2d) A/J(H-2a)	[63]	IHPFHILIALETYKT	1485
	H 306–325	EKLCNEKLLKKARIHPFHIL	SJL/L (H-2s)	[63]	EKLLKKARIHPFHIL	1721
	H 26–45	QVTDMNRLHRFLCFGSEGGT	SJL/L (H-2s)	[63]	QVTDMNRLHRFLCFG	2266
	H 401–425	MVVTREKDSYVVAFSDEMVPCPVT	SJL/L (H-2s) A/J(H-2a)	[63]	REKDSYVVAFSDEMV	2879
	H 481–505	IALREYRKKMDIPAKLIVCGMSTNG	SJL/L (H-2s)	[63]	REYRKKMDIPAKLIV	622
	H 201–225	YITKGWKEVHELYKEKALSVETEKL	BALB/c (H-2d)	[63]	VHELYKEKALSVETE	2191
	H 241–265	ELEVIHLIEEHRLLTNHLKS	BALB/c (H-2d) A/J(H-2a)	[63]	VIHLIEEHRLLTNHL	130
Ro52	Full peptide	Full protein	New Zealand Mixed Mice (NZMZ) 2758	[64]	NPWLILSEDRRQVRL	28
Ro60	480–494	AIALREYRKKMDIPA	Animals were immunized with peptide Ro480–494	[65,66]	AIALREYRKKMDIPA	1876
	274–290	QEMPLTALLRNLGKMT	Animals were immunized with peptide Ro274–290	[65,66]	EMPLTALLRNLGKMT	1598
	274–290	Human QEMPLTALLRNLGKMT	Amino acid sequences of the human 60-kd Ro peptides used for immunization of BALB/c mice	[67]	EMPLTALLRNLGKMT	1598
		Mouse QEMPLTALLRNLGKMT
	413–428	Human VAFSDEMVPCPVTTDM
		Mouse VAFACDMVPFPVTTDM
		Rabbit VAFSDEMVPCPLTTDM
	480–495	Human AIALREYRKKMDIPA			VAFSDEMVPCPVTTD	20,917
		Mouse AVALREYRKKMDIPA			AIALREYRKKMDIPA	1876
La	1–107	GYVDISLLVSFNKMKKLTTDGKLIARALKSSSVVELDLEGTRIRRKKPLGERPKDEEERTVYVELLPKNVTH		[68]	MKKLTTDGKLIARAL	136
	243–345	KAKKRAQKDGVGQAASEVSKESRDLEFCSTEEEKETDRKGDSLSKVKRKHKKKHKERHKMGEEVIPLRVLSKTEWMDLKKEYLALQKASMASLKKTISQ			SKTEWMDLKKEYLAL	922
	111–242	EQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPSLRVAEEKKKKKKKKGRIKKEESVQAKESAVDSSSSGVCKATKRPRTASEGSEAETPEAPKQPAKKKKKRDKVEASSLPEARAGKRERCSAEDEDCL			SSSGVCKATKRPRTA	561