Table 2.
Antiparasitic and antibacterial activity of G4 ligands. Structures are depicted in Figure 6.
| IC50/µM | |||||
|---|---|---|---|---|---|
| G4 Ligand | P. falciparum | T. brucei | L. major | M. tuberculosis | Human Cells |
| TMPyP4 | 35 [114]; 0.62 [51] | >10 [115] | 21 [115] | 6.25 [116] | >25 [115] |
| TMPyP2 | 11 [51] | ||||
| Telomestatin | 5 [114] | ||||
| 3AQN | 1.8–2.5 [117] | 170 [117] | |||
| 6AQN | 1.5–2.7 [117] | 170 [117] | |||
| PDC-360A | 0.9–1.2 [117] | 120 [117] | |||
| Carb-NDI6 | 0.275 [115] | 0.017 [115] | 0.537 [115] | 0.71 [115] | |
| Pyridostatin | 2.65 [115]; 5.2 [53] | 7.82 [115] | 5.00 [115] | 5.38 [115] | |
| BRACO-19 (a) | 9.70 [115] | 5.51 [115] | 12.7 [115] | <12.5 [118] | 8.33 [115] |
| Quarfloxin (a) | 0.11 [51] | ||||
| c-exNDI 2 | <2.5 [118] | ||||
| PIPER-d3 | 0.027 [119] | >100 [119] | 2.5–53 [119] | ||
(a) Structure in Figure 4.