Table 1.
Cohort descriptions
| Ascertainment | Cohort | Array type | n= | Females, n (%) | Age in years Mean (SD) |
Type of intelligence measures | Z-scored intelligence measure Mean (SD) |
|---|---|---|---|---|---|---|---|
| Unselected (n=20,151) | IMAGEN | 610Kq; 660Wq | 1,744 | 891 (51%) | 14.4 (0.4) | WISC-IV (and g-factor, similarities score, vocabulary score, block design score, matrix reasoning score) | 0.44 (0.98) *** |
| SYS children | 610Kq; HOE-12V | 967 | 505 (52%) | 15.0 (1.8) | WISC-III (and g-factor using 63 cognitive measures†) | 0.30 (0.87) *** | |
| SYS parents | HOE-12V | 602 | 321 (53%) | 49.5 (4.9) | g-factor, 12 cognitive measures‡ | 0 (1) | |
| LBC1936 | 610Kq | 504 | 247 (49%) | 70.0 (-)* | Moray House Test (and g-factor) | 0.05 (0.96) *** | |
| CaG-GSA | GSA | 2,074 | 1,094 (53%) | 54.3 (7.6) | g-factor, Reasoning, Memory, Reaction time | −0.02 (1.03) | |
| CaG-Omni2.5 | Omni2.5 | 515 | 281 (55%) | 52.4 (8.6) | −0.10 (1.02) | ||
| CaG (all) | GSA; Omni2.5 | 2,589 | 1,375 (53%) | 53.9 (7.8) | −0.03 (1.03) | ||
| G-Scot | 610Kq | 13,745 | 8,101 (59%) | 46.7 (15.0) | g-factor, Logical Memory, Digit Symbol, Verbal fluency, Mill Hill Vocabulary | 0.00 (0.99) | |
| Autism (n=3,941) | SSC-1Mv1 | 1Mv1 | 332 | 44 (13%) | 9.5 (3.2) | WISC-IV n=19; DAS-II E-Y n=96; DAS-II S-A n=179; Mullen n=12; WASI-I n=26 | −0.55 (1.59) |
| SSC-1Mv3 | 1Mv3 | 1,182 | 157 (13%) | 8.8 (3.5) | WISC-IV n=16; DAS-II E-Y n=531; DAS-II S-A n=539; Mullen n=77; WASI-I n=19 | −0.98 (1.66) | |
| SSC-Omni2.5 | Omni2.5 | 1.048 | 140 (13%) | 9.2 (3.7) | WISC-IV n=10; DAS-II E-Y n=403; DAS-II S-A n=494; Mullen n=124; WASI-I n=17 | −1.25 (1.87) | |
| SSC (all) | 1Mv1; 1Mv3; Omni2.5 | 2,562 | 341 (13%) | 9.03 (3.6) | WISC-IV n=45; DAS-II E-Y n=1,030; DAS-II S-A n=1,212; Mullen n=213; WASI-I n=62 | −1.03 (1.75) | |
| MSSNG | WGS | 1,379 | 275 (20%) | 9.2 (4.4) | WISC-IV n=46; WASI-II n=338; Leiter n=372; Raven n=214; Standford Binet n=281; WPPSI n=128 | −0.47 (1.58) | |
| NDD** (n=282) | Ste-Justine-probands | Agilent 180 K array | 75 | 29 (35%) | 7.23 (4.46) | WISC-V n=25; WASI-II n=5; WPPSI-IV n=23; Leiter-R n=11; Mullen n=19 | −1.34 (0.96) |
| Ste-Justine-siblings | 37 | 17 (46%) | 10.06 (6.62) | WISC-V n=12; WASI-II n=9; WPPSI-IV n=11; Leiter-R n=2; Mullen n=3 | −0.26 (1.06) | ||
| Ste-Justine-parents | 170 | 100 (59%) | 37.72 (6.88) | WASI-II | −0.12 (1.13) |
Cohorts include 24,092 individuals, including 14,874 unrelated individuals. SSC and CaG cohorts were broken down into sub-samples based on array technology (Supplementary methods).
†63 and ‡ 12 cognitive measures were respectively used to compute the g-factor in SYS children and parents (Supplementary methods). NDD: neurodevelopmental disorders, SYS: Saguenay Youth Study, CaG: CARTaGEN, LBC: Lothian Birth Cohort, SSC: Simons Simplex Collection; n=number of individuals remaining for analysis after quality control. The mean and Standard Deviation (SD) for g-factor slightly deviate from 0 and 1 in some cohorts since it was computed on all available data (before the exclusion of some individuals for poor quality array) and summarized here only for individuals included in the analyses.
All individuals from LBC1936 were assessed at 70 years old explaining the absence of SD computation.
The NDD cohort was used only in the replication analysis and was not included in meta- or mega-analyses.
We displayed the Z-scored of IQ, because IQ was preferred to g-factor for all analyses, even if results were similar (Supplementary table 1 and 3).