Table 3.

Univariate (a) and multivariate (b) risk factor analysis of significant hepatic fibrosis.

Variables	OR	CI (95%)	p-Value
(a) Univariate analysis
Age	1.04	1.03–1.05	<0.001
Male sex	2.13	1.50–3.02	<0.001
BMI (kg/m2)	1.12	1.09–1.16	<0.001
Fatty liver (≥mild)	1.56	1.26–1.93	<0.001
Hypertension	1.69	1.36–2.11	<0.001
Metabolic risk abnormalities (≥2)	2.54	2.03–3.17	<0.001
Metabolic risk abnormalities (≥3)	2.37	1.91–2.95	<0.001
Diabetes	3.77	2.89–4.92	<0.001
Metabolically unhealthy status	2.50	1.99–3.12	<0.001
Abnormal aminotransferase	2.96	2.39–3.68	<0.001
Component of metabolic risk abnormality
Central obesity	1.98	1.60–2.45	<0.001
High blood pressure or hypertension medication	1.44	1.14–1.82	0.002
High triglyceride	1.58	1.27–1.95	<0.001
Low HDL or dyslipidemia medication	1.33	1.04–1.72	0.023
Prediabetes or diabetes	2.71	2.19–3.36	<0.001
(b) Multivariate analysis
Age	1.04	1.03–1.05	<0.001
Male sex	1.85	1.29–2.65	0.001
Fatty liver (≥mild)	0.86	0.67–1.10	0.256
Abnormal aminotransferase	2.80	2.21–3.55	<0.001
Metabolically unhealthy status	1.76	1.37–2.26	<0.001

Odds ratios for significant hepatic fibrosis in (a) univariate analysis were calculated using the chi-square test. Odds ratios of fatty liver or metabolically unhealthy status for significant fibrosis in (b) multivariate analysis were evaluated through the multi-variate logistic regression analysis. Abbreviations: BMI, body mass index; OR, odds ratio; CI, confidence interval; HDL, high-density lipoprotein.