TABLE 3.
MICs of fluoroquinolones and macrolides for S. pneumoniae
Antimicrobial class and agent (no. of strains) | % (cumulative %) of strains for which the MIC (μg/ml) is as follows:
|
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
≤0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | ≥64 | |
Fluoroquinolones | ||||||||||||
Grepafloxacin (1,275) | 0.5 (0.5) | 14.4 (14.9) | 71.8 (86.7) | 12.3 (99.0)a | 0.8 (99.8) | 0.1 (99.8) | 0.1 (99.8) | 0.1 (99.9) | 0.1 (100) | |||
Sparfloxacin (1,276) | 0.1 (0.1) | 0.5 (0.6) | 17.6 (18.2) | 75.7 (93.9) | 5.6 (99.5) | 0.2 (99.7) | 0.2 (99.9) | 0.0 (99.9) | 0.0 (99.9) | 0.1 (100.0) | ||
Levofloxacin (1,274) | 0.1 (0.1) | 0.0 (0.1) | 0.1 (0.2) | 0.2 (0.4) | 65.4 (65.8) | 33.6 (99.4) | 0.4 (99.8) | 0.1 (99.9) | 0.1 (99.99) | 0.1 (100.0) | ||
Ciprofloxacin (1,275) | 0.1 (0.1) | 0.0 (0.1) | 0.4 (0.5) | 10.1 (10.6) | 61.3 (71.9) | 24.6 (96.5) | 3.0 (99.5) | 0.3 (99.8) | 0.0 (99.8) | 0.2 (100.0) | ||
Ofloxacin (1,275) | 0.2 (0.2) | 0.1 (0.3) | 0.1 (0.4) | 0.2 (0.6) | 0.8 (1.4) | 79.7 (81.1) | 18.5 (99.6) | 0.2 (99.8) | 0.0 (99.8) | 0.2 (100.0) | ||
Macrolides | ||||||||||||
Erythromycin (1,276) | 27.3 (27.3) | 46.8 (74.1) | 2.0 (76.1) | 0.3 (76.4) | 0.3 (76.7) | 0.7 (77.4) | 1.7 (79.1) | 5.8 (84.9) | 5.5 (90.4) | 3.8 (94.2) | 0.4 (94.6) | 5.4 (100.0) |
Clarithromycin (1,275) | 69.6 (69.6) | 6.3 (75.9) | 0.5 (76.4) | 0.3 (76.7) | 0.5 (77.2) | 1.5 (78.7) | 5.5 (84.2) | 4.8 (89.0) | 4.6 (93.6) | 1.2 (94.8) | 0.3 (95.1) | 4.9 (100.0) |
Azithromycin (1,275) | 7.2 (7.2) | 58.6 (65.8) | 10.9 (76.7) | 0.3 (77.0) | 0.2 (77.2) | 1.0 (78.2) | 2.2 (80.4) | 5.5 (85.9) | 4.8 (90.7) | 3.1 (93.8) | 6.2 (100.0) |
Values in boldface indicate percentage (cumulative percentage) of strains for which the MIC is the MIC90.