Figure 9.

The normalized a-wave (A,C,E,G) and b-wave (B,D,F,H) amplitudes are plotted versus the light intensity for all the treatment groups in Brown Norway rats (n = 4 per group). The amplitudes are shown ± the standard deviations. No significant differences could be observed at day one (baseline) between all the treatment groups. The treatment effects started to show from seven-days post-injection onwards. A significant and clear effect was observed for the 20 mg/kg treatment group for both the a- and b-wave. A 30 mg/kg dose caused moderate effects, and 50 mg/kg caused more extreme decreased amplitudes. From day 13 onwards, more long-term effects were visible. No significant differences were observed (anymore) between the control, 10 mg/kg, and 20 mg/kg groups. A significant, stable, and moderate effect was observed for the 30 mg/kg treatment group. Injection of 30 mg/kg SI caused a reduction of the a- and b-wave amplitudes of roughly 50% at least up to one-month post-injection. More extreme effects were observed for the higher dose (50 mg/kg). Almost non-recordable ERG responses were observed in this group. ns: not significant, *: p ≤ 0.05, **: p ≤ 0.01, ***: p ≤ 0.001, and ****: p ≤ 0.0001.3.