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WAS induces visceral and somatic hypersensitivity in female rats that is blocked by exposure to EE. (A) Experimental design. (B) WAS increased the FPO of rats compared to SHAM for both SH and EE rats (p < 0.01). (C) EE for 1 week before and during WAS prevented the induction of visceral hypersensitivity at 40 mmHg (p < 0.05) and 60 mmHg (p < 0.001), and (D) also inhibited WAS-induced somatic hypersensitivity (p < 0.01) in female rats.
