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. 2021 Apr 21;118(5):1247–1261. doi: 10.1093/cvr/cvab140

Figure 5.

Figure 5

VT burden increases when PSC-CM patch thickness is increased. (A, E) Complete engraftment of PSC-CM patches with different radii (r = 1.6 and 3.2 cm) and thicknesses (depths = 0.3, 1, and 2 mm) was simulated at sites L1, L2 in (A) P1 and (E) P2; patch myofibres were aligned to the local myofibres (i.e. 0°). (B, F) Inducibility and VT burden of (B) P1 and (F) P2 for each transplantation site, (L1, left and L2, right) and for patches with smaller (purple) compared with larger (blue) radii across different patch thicknesses. (C, G) Normalized conduction velocity (relative to that of non-infarcted myocardium) vs. patch thickness for different transplantation sites and patch radii in (C) P1 and (G) P2. (D, H) Number of distinct VT morphologies across different patch radii and thicknesses in (D) P1 and (H) P2.