Figure 4.

Endothelial Zeb2-KO promotes intussusceptive angiogenesis. (A and B) Number of Erg⁺ ECs (A; n = 4) and % of Ki67⁺ Erg⁺ ECs (B; n = 4). Arrowheads indicate proliferating ECs. (C) Representative scanning EM images of vascular corrosion casts (left) or a liver slice (middle) of an EC^KO mouse and corresponding quantification (right) of number of intussusceptive pillars (n = 5–7). Arrowheads indicate pillars. Data are expressed as mean ± sem; *P < 0.05 by the Student’s t-test. Scale bars: 20 µm in C, left; 5 µm in C, middle. EC, endothelial cell; WT, wild-type.