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. 2022 Mar 2;58(3):365. doi: 10.3390/medicina58030365

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cellular and extracellular components of melanoma’s microenvironment. The tumour microenvironment (TME) contains numerous cellular and extracellular components, forming together a complex, which supports melanoma development. APCs—antigen-presenting cells; CAFs—cancer-associated fibroblasts; DCs—dendritic cells; EVs—extracellular vesicles; HMGB1- high mobility group box 1 protein; MDSCs—myeloid-derived suppressor cells; miRNAs—microRNAs; PMNs—neutrophils; TCRs—T cells receptors; Tregs—regulatory T cells; ↑—increased level; ↓—decreased level.