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. 2022 Mar 20;14(6):1308. doi: 10.3390/nu14061308

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of EF-2001 oral administration on HFD-induced accumulation of white adipose tissue and body weights of obese rats. (A) Workflow of experimental procedure in HFD-induced SD rats. Male rats were divided into standard diet (SD) or high fat diet (HFD), and rats were orally administered with refined water, 3 mg/kg EF-2001, or 30 mg/kg EF-2001 in water (n = 6 rats/group). Gavage was continued for 6 weeks. (B) Effects of EF-2001 on the weight of SD rats fed by standard diet and HFD for 6 weeks. Body weight was monitored each day. (C) Effects of EF-2001 on the accumulation of adipose tissue of HFD-induced obese rats. To investigate the weight of adipose tissue, the rats were sacrificed, and the abdomen was opened to take pictures. (D) Effects of EF-2001 on the weight of white adipose tissue of HFD-induced obese rats. Data was analyzed with white adipose tissue weight per body weight. Data are represented as the mean ± SEM. (n = 6); * p < 0.05 and ** p < 0.01 vs. control (without EF-2001 in HFD-induced obese rats).