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. 2022 Mar 11;23(6):3041. doi: 10.3390/ijms23063041

Figure 2.

Figure 2

Various formats of antibodies. Antibodies can be used as naked IgG or conjugated to various agents such as drugs (antibody–drug conjugates or ADC), radioisotopes (radioimmunoconjugates or RIC) and toxins (immunotoxins). IgGs can be engineered to target two different antigens (bispecific IgG). Single-chain fragment variables (scFv) can be fused to the IgG Fc domain to generate bivalent scFv–Fc fusion antibodies. scFvs targeting two different antigens can be fused to each other with a linker making them a bispecific antibody. T-cells can be engineered into chimeric antigenic receptor (CAR)-T cells where an scFv is expressed on their surface to target the desired antigen. Smaller antibody formats such as F(ab’)2 and Fab do not contain the Fc region of the IgG. Created with BioRender.com.