Table 3.
Phenome-wide association of genetically predicted expression of TAGLN in the UKBB
| Phenotype | Ntissues | Nindep | Best Sign | Consensus Sign | Pa |
|---|---|---|---|---|---|
| Platelet count | 47 | 5 | + | + | 3.5 × 10−16 |
| Platelet distribution width | 47 | 5 | − | − | 3.5 × 10−13 |
| Eosinophil count | 47 | 5 | + | − | 1.9 × 10−10 |
| Self-reported high cholesterol | 47 | 5 | − | + | 1.3 × 10−9 |
| Red blood cell (erythrocyte) distribution width | 47 | 5 | + | − | 2.8 × 10−9 |
| Platelet crit | 47 | 5 | + | + | 1.4 × 10−8 |
| Leg fat percentage (right) | 47 | 5 | − | − | 5.2 × 10−8 |
| Mean platelet (thrombocyte) volume | 47 | 5 | − | − | 5.9 × 10−8 |
| Eosinophil percentage | 47 | 5 | + | − | 6.5 × 10−8 |
| Leg fat percentage (left) | 47 | 5 | − | − | 1.6 × 10−7 |
| Cholesterol-lowering medication use | 47 | 5 | − | − | 1.0 × 10−6 |
| Waist circumference | 47 | 5 | − | − | 1.1 × 10−6 |
| Body fat percentage | 47 | 5 | − | − | 2.3 × 10−6 |
| Leg fat mass (right) | 47 | 5 | − | − | 2.7 × 10−6 |
| Hematocrit percentage | 47 | 5 | + | + | 3.0 × 10−6 |
| Treatment/medication code: fenofibrate | 47 | 5 | − | − | 3.4 × 10−6 |
| BMI | 47 | 5 | − | − | 4.2 × 10−6 |
| Leg fat mass (left) | 47 | 5 | − | − | 4.5 × 10−6 |
Ntissues, number of tissues available to S-MultiXcan when computing significance for a gene; Nindep, number of independent components of variations among Ntissues; Best sign, the sign of effect of the most significant tissue where “+” (“−”) means higher (lower) expression is associated with higher risk or higher value of the phenotype; Consensus sign, the sign of effect of the consensus among those tissues with P value <1 × 10−4 where “+“ (“−”) means the same as in the “Best sign” column.
a
Obtained using S-MultiXcan on GWAS summary statistics of UKBB phenotypes.