Fig. 1.

Pathway map summarizing the involvement of 25-HC in the immune response. The involvement of 26-HC in some of the pathways is also shown. Blue arrows signify a “process,” red arrows a chemical reaction, Τ signifies inhibition of a process, black arrows indicate transport, arrows with a diamond arrowhead indicate activation of a receptor, and green oval arrowheads indicate catalysis. Oxysterols are on a light green background, enzymes are on a dark green background, nuclear receptors are on a purple background, ILs on a dark salmon background, and end processes on a light salmon background. See supplemental data for oxysterol structures.