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Pathway map detailing the biosynthesis and metabolism of (A) 7α,25-diHC and (B) 7α,(25R)26-diHC and 7α,(25S)26-diHC. 7α,25-diHC and 7α,(25R)26-diHC are ligands toward GPR183 (shown on a dark gray background) as indicated by a diamond arrowhead; other symbols are as in Fig. 1. Proposed but unproven enzymes are underlined. Abbreviations for sterols are given in the text.
