Table 2.
An overview of developed vaccine strategies against human pathogens utilizing B. subtilis spores. The target protein, the disease/pathogen it belongs to, the vector used, the carrier protein, and the animal model used to study the effects in are listed.
| Target Protein | Disease/Pathogen | Vector | Carrier | Model | Reference |
|---|---|---|---|---|---|
| TTFC | Clostridium tetani | pGEM | CotB | Mouse | [193] |
| PA | Bacillus anthracis | pDG364 | CotB/CotC | Mouse | [195] |
| GST-Cpa247-370 | Necrotic enteritis | pDG1664 | CotB | Mouse | [196] |
| Toxin A/B | Clostridioides difficile | - | CotB | Mouse | [197] |
| FliD | Clostridioides difficile | pDL | CotB | - | [198] |
| VP1 | Enterovirus 71 | pDG1662 | CotB | Mouse | [199] |
| M2e3 | Influenza virus | pDG1664 | CotB | Mouse | [200] |
| MPT64 | Mycobacterium tuberculosis | pcotVac | CotB | Mouse | [201] |
| TTFC/LFB | Clostridium tetani/E. coli | pRH22/pIM51 | CotC | Mouse | [202] |
| CsTP22.3 | Clonorchis sinensis | pGEX | CotC | Rat | [203] |
| SjGST | Schistosomias | pGEX | CotC | Mouse | [204] |
| UreB | Helicobacter pylori | pUS186 | CotC | Mouse | [205] |
| Enolase | Clonorchis sinensis | PEB03 | CotC | Rat | [206] |
| CsPmy | Clonorchis sinensis | PEB03 | CotC | Mice | [190] |
| CagA | Helicobacter pylori | - | CgeA | - | [188] |
| TTFC | Clostridium tetani | pET28b | CotB | Mouse | [195] |
| TcdA | Clostridioides difficile | pET28b | CotB/CotC | Mouse | [207] |
| OmpC | Salmonella-serovar Pullorum/Typhimurium | pDG364 | CotC | Mouse | [208] |
| CsCP | Clonorchis sinensis | pEB03 | CotC | Mouse | [209] |
| TP20.8 | Clonorchis sinensis | pGEX | CotC | Rat | [210] |
| CsLAP2 | Clonorchis sinensis | PEB03 | CotC | Mouse | [211] |
| UreA | Helicobacter pylori | pGEM | CotC | - | [212] |
| SEB | Staphyloccocus aureus | pET28a | CotC | Mouse | [213] |
| gC/gD | Pseudorabies virus | p43NMK | - | Mouse | [214] |
| CsSerpin3 | Clonorchis sinensis | PEB03 | CotC | Mouse | [215] |
| PA | Bacillus anthracis | pMar3g | - | Mouse | [216] |