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. 2022 Mar 11;15(3):345. doi: 10.3390/ph15030345

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The changes from the baseline of the levels (mean ± SEM) of (a) cytokine IL-6 and (b) D-dimer in the blood of patients in group A (ADAPT-232) and group B (placebo) over the time from Day 1 to Day 21. Between-groups comparison of the changes of cytokine IL-6 level in the blood from the baseline over time shows no interaction (p = 0.4369) and no significant difference (p = 0.5879) between groups A and B. The ADAPT-232 treatment has no statistically significant effect on cytokine IL-6 in blood compared to placebo. Between-groups comparison of the changes of blood D-dimer level from the baseline over time shows no interaction (p = 0.8920) and no significant difference (p = 0.5782) between groups A and B. The ADAPT-232 treatment has no statistically significant effect on blood D-dimer compared to placebo. *—p < 0.05. For details of statistical analysis, see Supplement 2.