Table 1.
Baseline demographic characteristics, study outcome measures, and laboratory hematological and biochemical measurements.
| Unit | Group A ADAPT-232, n = 50 |
Group B Placebo n = 50 |
Signif. of Difference | |||
|---|---|---|---|---|---|---|
| Parameters | Mean | S.D. | Mean | S.D. | p-Value | |
| Age | years | 49.52 | 12.57 | 48.18 | 15.13 | 0.6312 a |
| Gender | Male/Female | 7/42 | 7/43 | |||
| BMI | kg/m2 | 26.93 | 4.054 | 26.62 | 4.750 | 0.7196 a |
| Start of symptoms | weeks | 2.720 | 0.6402 | 2.760 | 0.6247 | 0.7525 b |
| Compliance | % | 101.0 | 1.998 | 100.8 | 2.437 | 0.1804 b |
| Fatigue | A.U. | 1.694 | 0.585 | 1.780 | 0.648 | 0.489 a |
| Headache | A.U. | 1.184 | 0.565 | 1.100 | 0.707 | 0.518 a |
| Respiration problems | A.U. | 0.449 | 0.6145 | 0.4600 | 0.7060 | 0.876 b |
| Organoleptic disorders | A.U. | 0.5600 | 0.7602 | 0.4400 | 0.5014 | 0.778 b |
| Hair loss | A.U. | 0.8660 | 0.1237 | 0.8953 | 0.1266 | 0.4996 a |
| Body temperature increase | C | <37 | <37 | >0.05 | ||
| Cough | AU | 0.7347 | 0.6047 | 0.6000 | 0.6061 | 0.2711 a |
| Pain in muscles, chest, and joints | A.U. | 1.245 | 0.5962 | 1.160 | 0.6503 | 0.5002 a |
| Sweatiness | A.U. | 1.204 | 0.7065 | 1.120 | 0.7730 | 0.6417 b |
| Stay at home/sick-listed | days | 0.3265 | 0.4738 | 0.8000 | 2.356 | 0.6866 b |
| Physical activity | A.U. | 16.43 | 2.850 | 15.56 | 4.305 | 0.3702 b |
| Physical activity (daily walk) | min | 5.534 | 0.0628 | 5.162 | 0.0757 | 0.7004 a |
| Decreased attention (d2 test) | %E (errors) | 25.51 | 16.70 | 26.43 | 18.93 | 0.9849 b |
| Anxiety (mild 14–17; moderate 18–24; severe > 25) | HAM-A score | 16.46 | 5.388 | 16.44 | 4.634 | 0.8674 b |
| Depression (mild 8–10, moderate 11–14, severe > 15) | HADS score | 15.30 | 4.595 | 15.78 | 4.473 | 0.5978 a |
| Blood serum cytokines IL-6 (normal level < 5.186) | pg/mL | 6.443 | 10.95 | 5.883 | 3.919 | 0.3763 b |
| D-dimer (normal level < 250) | pg/L | 133.3 | 195.8 | 105.2 | 99.46 | 0.9492 b |
| C-reactive protein (normal level < 350) | mg/L | 5.578 | 8.313 | 10.35 | 18.74 | 0.6630 b |
| Creatinine (female 52–92, male 65–120) | μM | 77.18 | 11.50 | 75.50 | 10.69 | 0.5557 b |
| Total Leukocyte count, WBC | 103 u/L | 8.96 | 12.11 | 7.55 | 4.42 | 0.44 |
| Erythrocytes, RBC | 106 u/L | 4.57 | 0.39 | 4.63 | 0.46 | 0.51 |
| Hemoglobin, Hb | g/L | 128.26 | 11.77 | 130.84 | 11.39 | 0.27 |
| Hematocrit, HCT | % | 38.53 | 3.30 | 39.12 | 3.46 | 0.39 |
| Platelet Count | 103 u/L | 240.16 | 57.65 | 251.86 | 59.64 | 0.32 |
| Absolute Neutrophil count | 103 u/L | 60.89 | 8.30 | 60.49 | 8.60 | 0.81 |
| Total Lymphocyte count | 103 u/L | 31.13 | 7.75 | 30.03 | 9.33 | 0.52 |
| Monocyte count | 103 u/L | 2.79 | 3.43 | 3.05 | 3.40 | 0.70 |
| Eosinophil count | 103 u/L | 4.36 | 1.61 | 4.22 | 1.57 | 0.65 |
| Basophil count | 103 u/L | 0.09 | 0.24 | 0.07 | 0.22 | 0.75 |
| Erythrocyte sedimentation rate, ESR | mm/h | 19.56 | 11.18 | 15.94 | 9.53 | 0.08 |