TABLE 1.
Strains tested in this study and their previously publisheda resistance mechanisms
Patient | Isolate | Efflux pumpb expression level | ERG11 point mutation(s) |
---|---|---|---|
I | C23 | S405F heterozygote | |
I | C32 | No increase relative to C23 | No data |
I | C39 | Increased CDR1 and CDR2 signals relative to C23 | S405F homozygote |
II | C45 | ||
II | C18 | No increase relative to C45 | |
II | C46 | No increase relative to C45 | |
III | C33 | ||
III | C34 | No increase relative to C33 | S405F homozygote |
III | C26 | Increased CDR1 and CDR2 signals relative to C33 | S405F and Y132H homozygote |
III | C82 | Less pronounced increase in CDR1 and CDR2 signals relative to C33 | S405F homozygote |
IV | C27 | ||
IV | C37 | No increase relative to C27 | G464S and R467K homozygote |
IV | C40 | Increased CaMDR1 signal relative to C27 | G464S and R467K homozygote, Y132H heterozygote |
V | C43 | G129A heterozygote | |
V | C48 | Increased CDR1 and CDR2 signals relative to C43 | No data |
V | C56 | Increased CDR1 and CDR2 signals relative to C43 | G129A and G464S homozygote |