TABLE 5.
Sterol compositions of C. albicans isolates
| Sterol(s) | Avg % of [14C]acetate incorporation into total sterolsa
|
|||||
|---|---|---|---|---|---|---|
| C43
|
C48
|
C56
|
||||
| Control | 0.03 μM itraconazole | Control | 0.3 μM itraconazole | Control | 0.3 μM itraconazole | |
| Ergosterol | 89.2 | 0.6 | 60.4 | 10.4 | 73.7 | 17.3 |
| 3,6-Diol | 2.5 | 51.4 | 30.7 | 33.1 | 21.1 | 27.2 |
| Eburicol, lanosterol | 5.4 | 18.9 | 4.7 | 20.9 | 3.2 | 16 |
| Obtusifoliol | 1.7 | 13 | 1.7 | 13.9 | 1.3 | 15.3 |
| 14α-Methyl-fecosterol | 1.7 | 2.7 | ||||
| 14α-Methyl-ergosta-5,7,22,24(28)-tetraene-3βol | 12.7 | 6.6 | 1.3 | |||
| Obtusifolione | 1 | 3.5 | 15 | 1 | 20 | |
a
Results shown are averages of at least three independent experiments. The itraconazole IC50s for ergosterol synthesis were 0.002, 0.05, and 0.04 μM in strains C43, C48, and C56, respectively.