TABLE 7.
Nucleotide and amino acid substitutions in the blaTEM genes from P. mirabilis strains
| β-Lactamase and strain or enzyme | Mutation at the following nucleotide (substituted amino acid)a:
|
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 32b | 226 (8) | 263 (21) | 317 (39) | 346 (48) | 436 (78) | 477 (92) | 512 (104) | 604 (134) | 682 (160) | 692 (164) | 911 (237) | 914 (238) | 917 (240) | 925 (242) | 929 (244) | 990 (265) | |
| TEM-like | |||||||||||||||||
| TEM-1 (blaTEM-1A)c | GCC-TA | C (Phe) | C (Leu) | C (Gln) | A (Glu) | C (Gly) | G (Gly) | G (Glu) | G (Ala) | T (Thr) | C (Arg) | G (Ala) | G (Gly) | G (Glu) | G (Gly) | C (Arg) | C (Thr) |
| TEM-1 (blaTEM-1B)c | GCC-TA | T | T | T | |||||||||||||
| TEM-2 (blaTEM-2)c | GCT-TA | A (Lys) | G | T | C | A | |||||||||||
| CF579 (TEM-57) | GCTATA | G | T | A (Asp) | C | A | |||||||||||
| ESBL | |||||||||||||||||
| CF249 (TEM-24) | GCT-TA | A (Lys) | G | T | A (Lys) | C | A (Ser) | A (Thr) | A (Lys) | A | |||||||
| CF39 (TEM-3) | GCT-TA | A (Lys) | G | T | A (Lys) | A (Ser) | A | ||||||||||
| CF669 (TEM-66) | GCT-TA | A (Lys) | G | T | A (Asp) | A (Lys) | A (Ser) | ||||||||||
| IRT-like | |||||||||||||||||
| CF449 (TEM-44 [IRT-13]) | GCT-TA | A (Lys) | G | T | C | A | A (Ser) | ||||||||||
| CF659 (TEM-65 [IRT-16]) | GCT-TA | A (Lys) | G | C | A | T (Cys) | |||||||||||
| CF739 (TEM-73 [IRT-18]) | GCT-TA | T (Phe) | C | G | T | C | A | T (Cys) | T (Met) | ||||||||
| CF749 (TEM-74 [IRT-19]) | GCT-TA | T (Phe) | C | G | T | C | A | A (Ser) | T (Met) | ||||||||