TABLE 1.

Cytokine concentrations in culture supernatants of Jurkat T cells: inhibitory effects of EM and FK506

Stimulant (concn [μM])	Concn (pg/ml)a
	IL-8	IL-2
NS	<1	<1
PMA	208 ± 33	<1
P-I	480 ± 66	2,877 ± 302
P-I + EM (0.1)	450 ± 23	2,901 ± 480
P-I + EM (1)	408 ± 66	2,657 ± 200
P-I + EM (10)	334 ± 79b	2,520 ± 363
P-I + FK506 (0.1)	167 ± 26c	261 ± 53c

^aData represent means ± standard deviations of IL-8 or IL-2 concentrations in culture supernatants from three independent experiments. NS, nonstimulated; P-I, PMA (20 ng/ml) plus ionomycin (2 μM). 

^bP < 0.05. 

^cP < 0.01.