Table 2.
Drugs that can worsen specific seizure types in patients with IGEs
| Antiseizure medicine | Seizure type that can worsen | Can precipitate absence/myoclonic status epilepticus |
|---|---|---|
| Carbamazepine | Absence, myoclonus | Yes |
| Phenytoin | Absence, myoclonus | Yes |
| Ethosuximide* | GTCS | No |
| Phenobarbitone# | Absence | No |
| Clonazepam/Clobazam# | Absence | No |
| Gabapentin | Myoclonus, absence | No |
| Vigabatrin | Myoclonus, absence | Yes |
| Tiagabine | Myoclonus, absence | Yes |
| Lamotrigine | Myoclonus | No |
| Levetiracetam# | Absence | No |
*Probably related to ineffectiveness of ethosuximide against generalized tonic-clonic seizures. # Single case reports; not replicated. GTCS: Generalized tonic-clonic seizure