Table 4.
Clinical baseline characteristics and IVF outcome of the overall patients’ population (n = 1470) receiving COS with either rFSH + rLH (n = 801) or rFSH alone (n = 669), stratified according to the POSEIDON classification. Data are expressed as mean ± standard deviation or as absolute values and percentage, as appropriate.
| rFSH + rLH | rFSH Alone | ||
|---|---|---|---|
| (n = 801) | (n = 669) | p | |
| POSEIDON Group 1 | (n = 55, 7%) | (n = 212, 32%) | |
| Age (years) | 31.0 ± 2.5 | 31.3 ± 2.3 | 0.46 |
| AMH (ng/mL) | 1.9 ± 0.5 | 1.9 ± 0.4 | 0.38 |
| Antral follicle count (AFC) | 10.9 ± 3.2 | 12.1 ± 2.9 | <0.05 |
| Retrieved oocytes (n) | 7.8 ± 4.5 | 9.2 ± 4.3 | <0.05 |
| Mature (MII) oocytes (n) | 6.1 ± 4.2 | 7.2 ± 3.3 | 0.08 |
| Fertilization rate (%) | 71.2 ± 28.8 | 70.8 ± 23.5 | 0.92 |
| Top quality embryos (%) | 47.6 ± 34.0 | 56.2 ± 33.8 | 0.11 |
| Cumulative live birth rate/OPU % (n) | 36.4 (20/55) | 38.2 (81/212) | 0.80 |
| POSEIDON Group 2 | (n = 160, 20%) | (n = 269, 40%) | |
| Age (years) | 38.5 ± 2.3 | 38.0 ± 2.4 | <0.05 |
| AMH (ng/mL) | 1.8 ± 0.4 | 1.9 ± 0.4 | <0.01 |
| Antral follicle count (AFC) | 9.9 ± 3.2 | 11.1 ± 2.9 | <0.001 |
| Retrieved oocytes (n) | 7.0 ± 3.7 | 8.2 ± 3.8 | <0.01 |
| Mature (MII) oocytes (n) | 5.5 ± 3.0 | 6.5 ± 3.2 | <0.01 |
| Fertilization rate (%) | 68.8 ± 25.7 | 69.4 ± 26.6 | 0.84 |
| Top quality embryos (%) | 52.1 ± 36.5 | 52.4 ± 33.1 | 0.94 |
| Cumulative live birth rate/OPU % (n) | 24.4 (39/160) | 26.0 (70/269) | 0.70 |
| POSEIDON Group 3 | (n = 81, 10%) | (n = 61, 9%) | |
| Age (years) | 31.8 ± 1.9 | 31.2 ± 3.2 | 0.22 |
| AMH (ng/mL) | 0.6 ± 0.3 | 0.8 ± 0.2 | <0.0001 |
| Antral follicle count (AFC) | 7.1 ± 3.2 | 10.2 ± 3.6 | <0.001 |
| Retrieved oocytes (n) | 4.9 ± 3.0 | 6.8 ± 3.4 | <0.01 |
| Mature (MII) oocytes (n) | 3.7 ± 2.2 | 5.5 ± 3.0 | <0.001 |
| Fertilization rate (%) | 63.7 ± 30.7 | 62.6 ± 30.7 | 0.83 |
| Top quality embryos (%) | 60.7 ± 39.6 | 57.0 ± 39.4 | 0.60 |
| Cumulative live birth rate/OPU % (n) | 29.6 (24/81) | 26.2 (16/61) | 0.66 |
| POSEIDON Group 4 | (n = 505, 63%) | (n = 127, 19%) | |
| Age (years) | 39.2 ± 2.4 | 38.4 ± 2.7 | <0.01 |
| AMH (ng/mL) | 0.6 ± 0.3 | 0.7 ± 0.3 | <0.0001 |
| Antral follicle count (AFC) | 7.0 ± 2.9 | 8.6 ± 3.8 | <0.001 |
| Retrieved oocytes (n) | 4.1 ± 2.9 | 5.3 ± 3.2 | <0.0001 |
| Mature (MII) oocytes (n) | 3.4 ± 2.5 | 4.5 ± 3.0 | <0.001 |
| Fertilization rate (%) | 70.2 ± 33.1 | 65.5 ± 29.0 | 0.13 |
| Top quality embryos (%) | 52.4 ± 39.8 | 53.0 ± 36.6 | 0.88 |
| Cumulative live birth rate/OPU % (n) | 18.8 (95/505) | 22.8 (29/127) | 0.31 |