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. 2022 Mar 8;23(6):2933. doi: 10.3390/ijms23062933

Figure 3.

Figure 3

Loss of microglial InsR function has no effect on hypothalamic neuropeptide gene expression. (A–F) Relative gene expression of (A,D) Hcrt; (B,E) Agrp and (C,F) Npy from hypothalamic tissue There is a decrease in Hcrt expression in male InsR-Ctrl mice fed an HFD diet compared to Chow diet. Data presented for female InsR-Ctrl and InsR-KO mice fed a Chow diet (black), or HFD (green) and male InsR-Ctrl and InsR-KO mice fed a Chow diet (black) or HFD (blue), following 12 weeks of diet exposure (n = 6). Data are presented as mean ± SEM. * p < 0.05.