Table 2.
Top 30 Most Frequent Birth Defects Co-Occurring With Nonsyndromic Cleft Palate Alone (CP) and With Nonsyndromic Cleft Lip With or Without Cleft Palate (CL ± P), Texas Birth Defects Registry, 1999–2014 (N = 1884 CP; N = 5289 CL ± P).
| Description of co-occurring defecta | Number of cases with the defect combination (%) |
|---|---|
|
| |
| With CP | |
| Ostium secundum–type atrial septal defect | 93 (4.9) |
| Ventricular septal defect | 70 (3.7) |
| Anomalies of ear causing impairment of hearing | 40 (2.1) |
| Other deformities of feet | 35 (1.9) |
| Reduction deformities of brain | 29 (1.5) |
| Other unspecified anomalies of face and neck | 29 (1.5) |
| Other anomalies of aorta | 27 (1.4) |
| Microcephalus | 25 (1.3) |
| Congenital hydrocephalus | 24 (1.3) |
| Polydactyly | 24 (1.3) |
| Syndactyly | 20 (1.1) |
| Obstructive defects of renal pelvis and ureter | 20 (1.1) |
| Anomalies of spine | 18 (1.0) |
| Other specified anomalies of the heart | 17 (0.9) |
| Other specified anomalies of unspecified limb | 17 (0.9) |
| Varus (inward) deformities of feet | 16 (0.8) |
| Other anomalies of ribs and sternum | 16 (0.8) |
| Other anomalies of lower limb including pelvic girdle | 15 (0.8) |
| Anencephalus | 15 (0.8) |
| Other anomalies of upper limb including shoulder girdle | 14 (0.7) |
| Microphthalmos | 14 (0.7) |
| Anomalies of pulmonary artery | 14 (0.7) |
| Renal agenesis and dysgenesis | 14 (0.7) |
| Atresia and stenosis of large intestine rectum and anal canal | 12 (0.6) |
| Reduction defects of upper limb | 12 (0.6) |
| Other specified anomalies of ear | 12 (0.6) |
| Other specified anomalies of brain | 11 (0.6) |
| Tricuspid atresia and stenosis | 11 (0.6) |
| Anomalies of pulmonary valve | 11 (0.6) |
| Other anomalies of intestine | 11 (0.6) |
| With CL ± P | |
| Ostium secundum type atrial septal defect | 234 (4.4) |
| Ventricular septal defect | 171 (3.2) |
| Reduction deformities of brain | 133 (2.5) |
| Microcephalus | 96 (1.8) |
| Other deformities of feet | 84 (1.6) |
| Anomalies of ear causing impairment of hearing | 80 (1.5) |
| Other anomalies of nose | 76 (1.4) |
| Anencephalus | 66 (1.2) |
| Polydactyly | 60 (1.1) |
| Obstructive defects of renal pelvis and ureter | 60 (1.1) |
| Congenital hydrocephalus | 59 (1.1) |
| Syndactyly | 47 (0.9) |
| Other unspecified anomalies of face and neck | 39 (0.7) |
| Anomalies of spine | 38 (0.7) |
| Other anomalies of aorta | 37 (0.7) |
| Reduction defects of upper limb | 33 (0.6) |
| Other anomalies of ribs and sternum | 32 (0.6) |
| Anomalies of great veins | 32 (0.6) |
| Microphthalmos | 32 (0.6) |
| Other specified anomalies of the heart | 31 (0.6) |
| Renal agenesis and dysgenesis | 31 (0.6) |
| Anomalies of pulmonary artery | 28 (0.5) |
| Other anomalies of lower limb including pelvic girdle | 28 (0.5) |
| Other specified anomalies of ureter | 26 (0.5) |
| Anomalies of pulmonary valve | 25 (0.5) |
| Other specified anomalies of ear | 25 (0.5) |
| Varus (inward) deformities of feet | 24 (0.5) |
| Other specified anomalies of brain | 23 (0.4) |
| Congenital anomalies of posterior segment | 23 (0.4) |
| Coloboma and other anomalies of anterior segments | 23 (0.4) |
a
BPA codes for defects included in the analysis specified in Supplementary material.