Table 4.

Birth Defect Combinations Co-Occurring With Nonsyndromic Cleft Lip With or Without Cleft Palate (CL ± P) With the Top 30 Ratios of Observed-to-Expected Prevalence, Texas Birth Defects Registry, 1999–2014 (N = 5289).

Description of co-occurring defectsa	Number of cases with the defect combination	O/Eadj ratiob
Congenital hydrocephalus, anophthalmos, other anomalies of nose	3	604.7
Reduction deformities of brain, anophthalmos, obstructive defects of renal pelvis and ureter	3	459.6
Reduction deformities of brain, anophthalmos, microphthalmos	3	452.8
Reduction deformities of brain, anophthalmos, other anomalies of nose	4	276.8
Anomalies of ear causing impairment of hearing, renal agenesis and dysgenesis, anomalies of spine	3	269.3
Microphthalmos, congenital anomalies of eyelids lacrimal system and orbit, other unspecified anomalies of face and neck	4	263.8
Coloboma and other anomalies of anterior segments, congenital anomalies of eyelids lacrimal system and orbit, other unspecified anomalies of face and neck	3	263.4
Anophthalmos, other anomalies of nose	8	259.7
Microcephalus, reduction deformities of brain, other anomalies of nose	18	236.3
Microcephalus, reduction deformities of brain, ventricular septal defect, other anomalies of nose	5	220.4
Microphthalmos, coloboma and other anomalies of anterior segments, congenital anomalies of eyelids lacrimal system and orbit	3	196.6
Anomalies of great veins, renal agenesis and dysgenesis, anomalies of spine	3	157.7
Microphthalmos, coloboma and other anomalies of anterior segments, other unspecified anomalies of face and neck	3	156.2
Anomalies of great veins, atresia and stenosis of large intestine rectum and anal canal, renal agenesis and dysgenesis	3	155.2
Anophthalmos, other unspecified anomalies of face and neck	4	150.7
Reduction deformities of brain, other anomalies of nose	32	147.2
Reduction deformities of brain, congenital anomalies of posterior segment, other anomalies of nose	5	141.9
Congenital hydrocephalus, tricuspid atresia and stenosis, congenital mitral stenosis	3	134.9
Reduction deformities of brain, anophthalmos	9	131.7
Anomalies of ear causing impairment of hearing, renal agenesis and dysgenesis, other anomalies of ribs and sternum	3	131.2
Anophthalmos, microphthalmos	3	129.4
Reduction deformities of brain, microphthalmos, other anomalies of ribs and sternum	3	123.4
Varus (inward) deformities of feet, anomalies of adrenal gland	3	122.8
Microcephalus, reduction deformities of brain, ostium secundum–type atrial septal defect, other anomalies of nose	3	119.0
Congenital hydrocephalus, anophthalmos	4	114.0
Microcephalus, ventricular septal defect, other anomalies of nose	5	113.9
Ventricular septal defect, anomalies of great veins, anomalies of spine	3	110.3
Microcephalus, other anomalies of nose	21	110.0
Anophthalmos, obstructive defects of renal pelvis and ureter	3	105.1
Reduction deformities of brain, ventricular septal defect, other anomalies of nose	6	100.8

^aBPA codes for defects included in the analysis specified in Supplementary material.

^bAdjusted observed-to-expected (O/E_adj) prevalence ratio.