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. 2022 Mar 3;10(3):395. doi: 10.3390/vaccines10030395

Figure 1.

Figure 1

Figure 1

Four possible combinations of toxicity and pathogenicity of influenza virus for mice. Virus 1—A/California/07/2009; virus 2—A/Bolivia/559/2013; virus 3—A/Mississippi/10/2013; virus 4—A/New Hampshire/04/2013; virus 5—A/South Africa/3626/2013; virus 6—A/Florida/62/2014; virus 7—A/Laos/1187/2014; virus 8—A/New York/61/2015; virus 9—A/Slovenia/2903/2015; virus 10—A/Bangladesh/3002/2015; virus 11—A/Newcastle/67/2017; virus 12—A/South Australia/272/2017; virus 13—A/New Jersey/13/2018; virus 14—A/Darwin/123/2018; virus 15—A/Brisbane/02/2018; virus 16—A/lowa/59/2018; virus 17—A/lowa/12/2019; virus 18—A/Victoria/2570/2019; virus 19—A/Guangdong-Maonan/SWL1536/2019; virus 20—A/Arkansas/08/2020; virus 21—A/Indiana/02/2020. X-axis—days post-infection. Y-axis—lethality, %. (a) the virus is toxic but not pathogenic for mice; (b) the virus is toxic and pathogenic for mice; (c) the virus is non-toxic and non-pathogenic for mice; (d) the virus is non-toxic but pathogenic for mice. The fourth variant is possible only theoretically. So far, we have not encountered strains with a similar combination of features. As for the other three variants, all the viruses studied were distributed as follows. Group (iii) includes five viruses: A/California/7/2009, A/Slovenia/2903/2015, A/New Jersey/13/2018, A/Darwin/123/2018, and A/Indiana/02/20. Group (ii) included six viruses: A/South Africa/3626/2013, A/Bolivia/559/2013, A/New Hampshire/04/2013, A/Laos/1187/2014, A/Florida/62/2014 and A/Bangladesh/3002/2015 and the first group (i) which has most of the viruses (consisted of ten viruses): A/Mississippi/10/2013, A/New York/61/2015, A/South Australia/272/2017, A/Newcastle/67/2017, A/Iowa/59/2018, A/Brisbane/02/2018, A/Victoria/2570/2019, A/Guangdong-Maonan/SWL1536/2019, A/Iowa/12/2019 and A/Arkansas/08/2020.