Table 1 –
Characteristics of clusters derived from hallmark gene set transcriptomic activation profiles in the initial dataset (n = 2138).
| High genomic risk (gray) n = 325 |
Low genomic risk (brown) n = 383 |
Blue cluster n = 624 |
Purple cluster n = 806 |
p value | |
|---|---|---|---|---|---|
| Age, median (IQR) | 66 (61–70) | 66 (61–67) | 67 (61–71) | 67 (61–71) | 0.9 |
| Preoperative PSA, median (IQR) | 8.0 (5.2–13.9) | 6.8 (4.8–11.3) | 7.2 (5.3–11.6) | 7.8 (5.5–12.1) | 0.041 |
| Gleason score, n (%) | |||||
| 4 + 5 | 263 (81) | 308 (80) | 493 (79) | 675 (84) | 0.08 |
| 5 + 4 | 52 (16) | 62 (16) | 119 (19) | 120 (15) | |
| 5 + 5 | 10 (3.1) | 13 (3.4) | 12 (1.9) | 11 (1.4) | |
| Seminal vesicle invasion, n (%) | 121 (42) | 178 (48) | 288 (47) | 309 (39) | 0.001 |
| Extraprostatic extension, n (%) | 229 (71) | 282 (75) | 488 (79) | 575 (73) | 0.02 |
| Lymph node involvement, n (%) | 49 (16) | 53 (15) | 97 (16) | 111 (14) | 0.8 |
| Positive surgical margins, n (%) | 181 (56) | 189 (50) | 334 (54) | 399 (50) | 0.2 |
| Average genomic risk score, median (IQR) | 0.69 (0.54–0.79) | 0.40 (0.31–0.50) | 0.47 (0.33–0.62) | 0.47 (0.34–0.64) | <0.001 |
| Decipher score, median (IQR) | 0.72 (0.50–0.85) | 0.47 (0.30–0.66) | 0.44 (0.22–0.75) | 0.46 (0.19–0.72) | <0.001 |
| PAM50 classifier, n (%) | |||||
| Basal | 23 (7.1) | 271 (71) | 224 (36) | 195 (24) | <0.001 |
| Luminal A | 20 (6.1) | 93 (24) | 207 (33) | 215 (27) | |
| Luminal B | 282 (87) | 19 (4.9) | 193 (31) | 396 (49) | |
| ERG-fusion positive, n (%) | 102 (31) | 147 (38) | 260 (42) | 231 (29) | <0.001 |
| PTEN status, n (%) | |||||
| Normal | 101 (31) | 323 (84) | 395 (63) | 461 (57) | <0.001 |
| Loss | 139 (43) | 15 (3.9) | 112 (18) | 171 (21) | |
| Indeterminate | 85 (26) | 45 (12) | 117 (19) | 174 (22) | |
| Androgen receptor activity, n (%) | |||||
| Average | 302 (93) | 182 (48) | 530 (85) | 748 (93) | <0.001 |
| Low | 23 (7.1) | 201 (52) | 94 (15) | 58 (7.2) | |
IQR = interquartile range; PSA = prostate-specific antigen.