. 2022 Mar 17;27(6):1953. doi: 10.3390/molecules27061953

Table 1.

Biological effects of natural compounds on psoriasis.

Natural Compounds	Biological Effects	References
Aloe vera L.	Immunomodulant and stimulant effect on macrophages, lymphocytes, and dendritic cells.	[187]
Aloe vera L.	Antidepressant effect.	[190,191]
Bergamot essential oil	Antibacterial and anti-psoriatic properties.	[193,195]
Bergamot essential oil	Moderation of mood disorders and stress-induced anxiety. Neuroprotective and sleep-inducing effect.	[194]
Quercetin	Decrease in TNF-α, IL-6, and IL-17 levels.	[202]
Quercetin	Regulation of cholinergic and sero-tonergic functions, anxiolytic and anti-depressant effects, enhances memory performance.	[203,204]
Baicalein	Antioxidant effect, inhibits the release of IL-17 and the expression of IL-6 and TNF-α.	[207,208]
Baicalein	Antidepressive and neuroprotective effect.	[183,209]
Curcumin	Decrease in IL-1β, IL-6, IL-22, and TNF-α levels.	[212]
Curcumin	Modulates serotonin, monoamine, noradrenaline, and dopamine. Regu-lates the function of the HPA axis.	[214,215]
Resveratrol	Reduces the secretion of inflammatory cytokines and induces apoptosis in keratinocytes. Inhibits the release of IL-17.	[220]
Resveratrol	Anxiolytic and antidepressant effect by inhibiting the expression of PDE4D, which regulates cAMP expression at the intracellular level.	[222]