Table 1.

Table of metadata concepts for WATCH-PD.

Device
Metadata Name		Pre-Specified Value?	Application-Dependent?	Metadata Item APDM	Metadata Item WATCH-PD
Device UID		No	No
Brand		Yes	No	APDM	Apple
Model		Yes	No	Opal	iPhone and Apple Watch
Hardware version		Yes	No	Opal v.2	Apple Watch Series 5 Apple iPhone 11
Firmware version		Yes	No	20190315	Apple Watch Series 5 Apple iPhone 11
Body site		Yes	No	Each wrist	Most affected wrist (Apple Watch)
Orientation		Yes	No	Sensors are positioned with device’s charging ports oriented toward more distal body locations	Watch orientation set during initial setup, with watch ‘crown’ positioned facing the hand. Watch on most-affected side
Hub/App		Yes	No	Mobility Lab Hub	BrainBaseline version ‘WATCH-PD’
Metadata version		Yes	No	V1.0	V1.0
Sensor and Signal
Sensor type		Yes	No	Accelerometer, Magnetometer, Gyroscope, Barometer	Accelerometer, Gyroscope
Recording mode		Yes	No	Active	Active
Calibration		Yes	No	Opal calibration process	N/A
Outputs	Datatype	No	No	Numeric	Numeric
	Serialization	No	No	TBD	TBD
	Units	No	No	os (gyro); m/s2 (accel); pT (mag); mPa (bar)	os (gyro); m/s2 (accel)
	Scaling	Yes	No	Accelerometer—100 um/s2 Gyroscope—10 urad/s Magnetometer—100 pT Barometer—100 mPa	-
	Filename of data file	No	No
Data rate		Yes	No	128 Hz from all sensors	100 Hz accel and gyro in clinic 50 Hz accel in home-base passive monitoring
Timing		Yes	No	Continuous data collection from all sensors during clinic assessment	Continuous data collection during clinic assessment. 7 day home based data collection
Multiple data streams		Yes	No	Accelerometer [xyz], Magnetometer [xyz], Gyroscope [xyz], Barometer	Accelerometer [xyz], Gyroscope [xyz]
Participant/Population
Subject UID		No	No
Demographics Inclusion/exclusion criteria		Yes	Yes	Inclusion criteria from WATCH-PD protocol	Inclusion criteria from WATCH-PD protocol
Comorbidities		No	Yes	Not available	Not available
Analysis Metadata
Data pre-processing		Yes	No	Not available	Not available
Endpoint analysis		Yes	Yes	WATCH-PD SAP v1.0	WATCH-PD SAP v1.0
Experiment
Experiment UID		Yes	No	WATCH-PD	WATCH-PD
Protocol		Yes	Yes	WATCH-PD Protocol v3.0	WATCH-PD Protocol v3.0
Questionnaires and scales		Yes	Yes	MDS-UPDRS 2.10	In-clinic: MDS-UPDRS 2.10 In-home: Single item 7-point Likert response indicating current tremor severity
Clinical assessments/Human observation		Yes	Yes	MDS-UPDRS 3.15, 3.16, 3.17; RUE 1 and LUE 2 assessments only	In-clinic: MDS-UPDRS 3.15, 3.16, 3.17; RUE and LUE assessments only In-home: N/A—No human observation during home assessments
Clinical follow-up frequency as a comparator for digital measures		Yes	Yes	Baseline, 1 month, 3 month, 6 month, 9 month, 12 month	Baseline, 1 month, 3 month, 6 month, 9 month, 12 month
Clinical correlations to digital measures		Yes	Yes	Sensor collection simultaneous with clinical assessments described above	In clinic, sensor collection simultaneous with clinical assessments described above
Active test details		Yes	Yes	Sensor collection simultaneous with clinical assessments as per protocol.	In clinic, sensor collection simultaneous with clinical assessment as per protocol.
Passive monitoring		Yes	Yes	N/A	At Home, 7 days passive monitoring.
Contextual Data
Environment		Yes	Yes	Clinic	Clinic, home
Environmental context (carer, temperature, indoor/outdoor, …)		Not available	Yes	Not available	Not available

¹ RUE: right upper extremity; ² LUE: left upper extremity; N/A: not applicable.