Figure 3:

Poor reversal performance is associated with higher midbrain D₃ BP_ND. (A-B) Average time activity curves in the six regions of interest extracted from either (A) [¹¹C]PHNO or (B) [¹⁸F]FPEB dynamic images. (C-D) Binding potential maps showing the distribution of (C) [¹¹C]PHNO and (D) [¹⁸F]FPEB binding in the rat brain. (E) [¹¹C]PHNO BP_ND in the midbrain was significantly greater in the poor reversal group compared to good reversal group. (F) No differences in [¹⁸F]FPEB BP_ND were observed between good and poor reversal groups. ** p<0.01; Abbreviations: mPFC – medial prefrontal cortex; OFC – orbitofrontal cortex; VS – ventral striatum; DS – dorsal striatum; MB – midbrain; Cbl – cerebellum.