Figure 5.

FD-compounds may target the lipid membrane of the enveloped virus. (A) FD-compounds bind to Vero E6 cells in a concentration-dependent manner; (B) HIV-1 Bal.01 PsVs were pretreated with FD001, and then added into target cells in the presence of recombinant unilamellar liposomes (size = 400 nm, 8:2 molar ratio of phosphatidylcholine (PC) to cholesterol) (left), while FD001 was pretreated with unilamellar liposomes (400 nm) and virus successively, and then added into target cells (right); (C) the liposome size was 100 nm, and the other conditions were the same as in B. Two-way ANOVA was used in the statistical analysis. **** and *** mean p < 0.0001 and p < 0.001, respectively.