TABLE 3.
Effects of dipyridamole on ribavirin disposition in peripheral blood
| Blood constituent | Ribavirin fraction | Ribavirin concn (μM)a
|
% Changeb | |
|---|---|---|---|---|
| Control | With dipyridamole | |||
| Plasma | Free | 17.6 ± 1.5 | 29.7 ± 2.8 | 68.8 |
| Phosphates | ND | ND | ||
| Total | 17.6 ± 1.5 | 29.7 ± 2.8 | 68.8 | |
| Whole blood | Free | 16.1 ± 1.7 | 23.0 ± 2.2 | 42.9 |
| Phosphates | 16.5 ± 0.7 | 9.9 ± 2.6 | −40.0 | |
| Total | 32.6 ± 1.8 | 32.9 ± 2.3 | 0.9 | |
| Erythrocytes | Free | 14.0 ± 5.8 | 14.0 ± 4.2 | 0.0 |
| Phosphates | 38.9 ± 1.5 | 23.3 ± 6.1 | −40.0 | |
| Total | 52.9 ± 5.6 | 37.2 ± 2.2 | −29.7 | |
a
Values are means ± SD. ND, not detected.
b
Change in ribavirin concentration as a result of dipyridamole treatment, with the control value set at 100%.