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. 2022 Mar 10;14(5):2062–2080. doi: 10.18632/aging.203945

Table 2. Meta-analyses and subgroup analyses for mortality.

Patients receiving immunotherapy vs. control patients N of studies Pooled OR (95%CI) a I 2 (%) b P P for interaction
Overall 14 0.92 (0.68, 1.25) 4% 0.61
Study type
Prospective 3 0.67 (0.43, 1.04) 0% 0.07 0.054
Retrospective 11 1.19 (0.81, 1.73) 0% 0.38
Number of patients
<100 6 0.64 (0.28, 1.49) 0% 0.30 0.39
>100 8 0.97 (0.63, 1.49) 34% 0.90
Cancer type
Hematological malignancies 3 0.72 (0.27, 1.91) 0% 0.51 0.48
Solid tumor 3 1.10 (0.69, 1.76) 36% 0.68
Non-specific cancer 8 0.72 (0.39, 1.33) 8% 0.29
Immunotherapy interval before the COVID-19 diagnosis (days)
>20 8 0.98 (0.56, 1.69) 25% 0.94 0.44
<20 2 1.23 (0.54, 2.76) 0% 0.62
Number of patients receiving active immunotherapy
<10 7 0.75 (0.27, 2.08) 22% 0.58 0.66
>10 7 0.95 (0.70, 1.28) 0% 0.73

aCalculated by using the random-effect model.

bI 2 means the inconsistency across studies.