Table 2.

The design expert results of all response variables.

Source	Size (nm)		EE%		CDR%
	F	p-Value	F	p-Value
Model	416.50	<0.0001	162.22	<0.0001	505.75	<0.0001
X1: GMS amount (mg)	1134.32	<0.0001	670.22	<0.0001	8.19	0.0133
X2: Poloxamer 407 (% w/w)	108.84	<0.0001	13.59	0.0050	173.20	<0.0001
X3: Oleic acid amount (mg)	6.34	0.0257	241.61	<0.0001	1335.85	<0.0001
X1×3			85.47	<0.0001
X12			54.30	<0.0001
X22			43.39	0.0001
X32			14.84	0.0039
Lack of Fit	0.3386	0.9183	0.4527	0.7962	0.9338	0.5748
Model	Linear		Reduced Quadratic		Linear
SD	0.1573		0.0003		1.01
R2	0.9897		0.9921		0.9915
Adequate precision	64.3041		42.7075		72.4640
Predicted R2	0.9845		0.9687		0.9849
Adjusted R2	0.9873		0.9860		0.9895
%CV	1.23		1.98		1.42
Sqrt (PS) = 12.7979 + 1.87247 × X1 − 0.580015 × X2 − 0.140025 × X3. 1/(EE) = 0.0121807 − 0.0024 × X1 + 0.0003 × X2 − 0.0014 × X3 + 0.0012 × X1 .X3 + 0.0009 × X12 + 0.0008 × X22 + 0.0005 × X32. CDR% = 71.2471 − 1.025 × X1 + 4.7125 × X2 + 13.0875 × X3.