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Pharmacokinetic parameters of BER-SOL (IV), BER-SOL (IN), and BER-CTS-NLCs (IN).
| Formulation | Tissue/Organ | Tmax (min) | Cmax (ng/mL) | Ke (min−1) | t1/2 (min) | AUC0–t (ng/mL × min) | Cbrain/Cblood at 30 min. | AUCbrain/AUCblood |
|---|---|---|---|---|---|---|---|---|
| BER-SOL (IV) | Brain | 30 | 780 | 0.005 | 128.5 | 74,944 | 0.26 | 0.24 |
| Blood | 15 | 4600 | 0.017 | 41.5 | 313,493 | |||
| BER-SOL (IN) | Brain | 45 | 748 | 0.005 | 144.6 | 137,275 | 2.14 | 0.99 |
| Blood | 45 | 1000 | 0.009 | 75.1 | 139,171 | |||
| BER-CTS-NLCs (IN) | Brain | 120 | 1033 | 0.003 | 247.2 | 469,403 | 4.56 | 1.22 |
| Blood | 120 | 1639 | 0.005 | 127.8 | 385,609 |
