Figure 2.

It has been shown that SPM levels are decreased in atherosclerosis, which influences the progression of the disease, given their proresolution role. These molecules decrease monocyte and neutrophil adhesion, as well as rolling. Additionally, SPM reduces proinflammatory cytokine synthesis, oxidative stress, and vascular smooth muscle cell migration while promoting plaque stability, collagen synthesis, macrophage prototype M2 activation, and efferocytosis, which reduces the size of the necrotic nucleus. ATL: Aspirin triggered lipoxins. LXA4: Lipoxin A4. LXB4: Lipoxin B4. RvD1: Resolvin D. RvD2: Resolvin D2. RvD3: Resolvin D3. RvE1: Resolvin E1. MaR1: Maresin 1. NOX: Nicotinamide adenine dinucleotide phosphate-oxidase. ROS: Reactive oxygen species. O2-: Superoxide.