Table 4.

Small organic molecules with the known biofilm inhibition or eradication mechanism.

	Small Organic Molecules	Biological Role	Effective Against	Type of Compound	Reference
1	5-phenyl-2-aminoimidazole	Reduction in transription of CsgD, csgB and adrA	S. typhimurium	Imidazole derivative	[79]
2	ABC-1	Reduction in SpA and PIA production and decrease eDNA release	S. aureus, Gram-positive and Gram-negative pathogens	Imidazole derivative	[1,80]
3	5,6-dimethoxy-2-aminobenzimidazole	Reduction in QS receptors (LasR and RhlR)	P. aeruginosa	Imidazole derivative	[81]
4	Pyrazolo-pyrimido [4,5-d] pyrimidines	ROS accumulation, loss of membrane integrity	M. luteus, S. aureus, B. subtilis, E. coli, K. planticola	pyrazole compound	[82,83,84]
5	Indole-3-carboxaldehyde and 3-indolylacetonitrile	Reduction of curli production	E. coli, P. aeruginosa	indole and carbazole derivative	[85,86]
6	Phenylhydrazine analogues	SrtA inhibition	S. aureus	2-Phenylhydrazineylidene derivatives	[87]
7	Diethyl 1-(2-chlorophenyl)-4-((3-chlorophenyl)amino)-5-oxo-2,5-dihydr-1H-pyrrole-2,3-dicarboxylate	MDH and eDNA inhibition	P. aeruginosa	Pyrrole derivatives	[90]
8	(Z)-5-bromomethylene-2(5H)-furanone	AI-2-mediated QS inhibition	S. anginosus, S.intermedius and S. mutans	Furanone and oxazolidinone derivatives	[91]
9	Bicyclic brominated furanones	AI-2-mediated QS inhibition	F. nucleatum, P. gingivalis and T. forsythia	Furanone and oxazolidinone derivatives	[91]
10	Halogenated phenazine	Bind with copper (II ) and iron (II)	MRSA, MRSE, and VRE	Phenazine and quinolone derivative	[92]
11	Quinolone compound Ia	PqsR inhibition	P. aeruginosa	Quinolone derivative	[93]
12	3,4-dimethoxycinnamide derivative	LecB inhibition	P. aeruginosa	Cinnamide derivative of d-mannose	[94]