Table 1.

Optimized formulations to prepare estradiol-loaded mucoadhesive buccal films.

Ingredients	F1	F2	F3	F4	F5	F6	F7	F8
Estradiol (g)						0.08	0.08	0.08
PVA (g)	0.5	0.5	0.75			0.75	1	1
HPMC (g)		1	1			1	1.5	1.5
PVP (g)							0.4	0.4
Kollicoat(g)				4	4
Xanthan (g)							0.015	0.015
Glycerin (mL)		0.2
PEG (mL)	1		1.5		0.5	1.5	2.5	2.5
Tween 80 (mL)							0.5	0.5
Transcutol (mL)								1
Ethanol (mL)							12
Citric acid (g)							0.125	0.125
Sucralose (g)							0.25	0.25
Water (QS) (mL)	50	50	50	50	50	50	50	50

F—formulation.