Table 6.
Release parameters of fitted experimental data for estradiol films prepared by cosolvency and nanoemulsion.
| Model Name | Equation | Goodness of Fit Parameter | Cosolvency Film | Nanoemulision Film |
|---|---|---|---|---|
| R2 adjusted | 0.9689 | 0.9768 | ||
| Zero order | F = k0 × t | RMSE | 6.4343 | 5.926 |
| AIC | 54.2245 | 33.0089 | ||
| R2 adjusted | 0.8511 | 0.8596 | ||
| First order | F = 100 × [1 − Exp(−k1 × t)] | RMSE | 14.0805 | 14.5686 |
| AIC | 68.3212 | 43.803 | ||
| R2 adjusted | 0.7687 | 0.7953 | ||
| Higuchi | F = kH × t0.5 | RMSE | 17.5484 | 17.5899 |
| AIC | 72.2843 | 46.0645 | ||
| R2 adjusted | 0.9837 | 0.9982 | ||
| Korsmeyer-Peppasb | F = kkP × tn | RMSE | 4.6546 | 1.6313 |
| AIC | 49.1944 | 18.1902 | ||
| R2 adjusted | 0.8924 | 0.8993 | ||
| Hixson-Crowell | F = 100 × [1 − (1 − kHC × t)3] | RMSE | 11.9675 | 12.3362 |
| AIC | 65.3945 | 41.8071 | ||
| R2 adjusted | 0.9933 | 0.9983 | ||
| Hopfenberg | F = 100 × [1 − (1 − kHB × t)n] | RMSE | 2.9814 | 1.6108 |
| AIC | 41.1765 | 18.0388 | ||
| R2 adjusted | 0.7007 | 0.7312 | ||
| Baker-Lonsdale | 3/2 × [1 − (1 − F/100)2/3] − F/100 = kBL × t | RMSE | 19.9617 | 20.1554 |
| AIC | 74.6036 | 47.6983 | ||
| R2 adjusted | 0.9841 | 0.9983 | ||
| Peppas-Sahlinc | F = k1 × tm + k2 × t2m | RMSE | 4.6033 | 1.604 |
| AIC | 49.6076 | 18.2614 | ||
| R2 adjusted | 0.9972 | 0.9912 | ||
| Weibull | F = 100 × {1 − Exp[− ((t − Ti)β)/α]} | RMSE | 1.9443 | 3.6431 |
| AIC | 34.0936 | 28.1058 |
Notes: F, Percentage of drug released at time t; k0, Zero order release constant; k1, First order release constant; kH, Higuchi release constant; kkP, Release rate constant, and bn, diffusional release exponent; kHC, Release constant relevant to Hixson–Crowell model; kHB, Combined constant corresponding to Hopfenberg model in which kHB = k0/(C0 × α0) where k0, erosion rate constant, C0, initial drug concentration in the matrix, α0, initial radius for a slab/cylinder/sphere structure, and n, 1, 2, and 3 for the slab, cylinder, and sphere structure, respectively; kBL, Combined constant related to Baker–Lonsdale model in which kBL = [3 × D × Cs/(r02 × C0)] where D, diffusion coefficient, Cs, saturation solubility, r0, initial radius for a sphere/cylinder/slab structure, and C0, initial drug concentration in the matrix; ck1, Constant relevant to the Fickian kinetics, and ck2, constant relevant to Case-II relaxation kinetics, and cm, diffusional release exponent; Abbreviations: R2 adjusted, adjusted coefficient of determination; RMSE, Root mean squared error; AIC, Akaike Information Criterion.