Table 2.
Specificity, sensitivity, positive and negative predictive value, and detection rate at different Phe cut-offs.
Number of newborns | 37,784 | ||||||||
Phe cut-off value (µmol/L) | 120 | 130 | 140 | 150 | 160 | 170 | 180 | 190 | 200 |
Recalls (N) | 108 | 41 | 21 | 16 | 12 | 11 | 11 | 9 | 9 |
False positive (N) | 102 | 35 | 15 | 10 | 6 | 5 | 5 | 3 | 3 |
True positive (N) | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
False negative (N) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
True negative (N) | 37,676 | 37,743 | 37,763 | 37,768 | 37,772 | 37,773 | 37,773 | 37,775 | 37,775 |
Detection rate (%) | 0.019 | 0.019 | 0.019 | 0.019 | 0.019 | 0.019 | 0.019 | 0.019 | 0.019 |
Sensitivity (%) | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Specificity (%) | 99.73 | 99.91 | 99.96 | 99.97 | 99.98 | 99.99 | 99.99 | 99.99 | 99.99 |
Positive predictive value (%) | 5.56 | 14.63 | 28.57 | 37.50 | 50.00 | 54.55 | 54.55 | 66.67 | 66.67 |
Negative predictive value (%) | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |