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. 2022 Mar 17;14(3):659. doi: 10.3390/pharmaceutics14030659

Table 1.

Summary of viscoelastic properties obtained in rheology for Ostenil® and different HA-L-PNIPAM 0.5 concentrations at 25 °C and 37 °C. HA contents for Ostenil® were calculated according to values obtained in 1H NMR spectroscopy.

Viscosupplement HA Content (mg/mL) Temperature (°C) Frequency: 0.5 Hz
G′ (Pa) G″ (Pa)
Ostenil® 10.0 25 8.24 ± 0.60 13.01 ± 0.75
37 5.35 ± 0.46 10.30 ± 0.64
HA-L-PNIPAM 0.5 7% 9.9 25 2.12 ± 2.27 3.37 ± 1.97
37 150.39 ± 31.90 62.60 ± 15.88
HA-L-PNIPAM 0.5 5% 7.1 25 0.01 ± 0.01 0.22 ± 0.01
37 29.11 ± 3.01 11.97 ± 3.10
HA-L-PNIPAM 0.5 1% 1.4 25 0.02 ± 0.01 0.03 ± 0.01
37 0.38 ± 0.15 0.27 ± 0.02