TABLE 3.
Titers in vegetations of rabbits treated with levofloxacin or penicillin for penicillin-susceptible and -resistant strains of viridans group streptococci
| Strain | Treatment (dosage) | Vegetation titer (log10 CFU/g [no. of rabbits]) |
|---|---|---|
| S. sanguis M99, penicillin susceptible | No treatment | 8.1 ± 0.3 (7) |
| Penicillin (300,000 U t.i.d.) | 4.4 ± 2.1 (13)a | |
| Levofloxacin (20 mg/kg b.i.d.) | 8.3 ± 0.6 (13)bc | |
| Levofloxacin (40 mg/kg b.i.d.) | 6.9 ± 1.6 (10)bc | |
| S. mitis 543, penicillin resistant | No treatment | 7.7 ± 0.58 (4) |
| Penicillin (300,000 U t.i.d.) | 4.1 ± 3.8 (5)b | |
| Levofloxacin (40 mg/kg b.i.d.) | 5.5 ± 2.7 (5)b |
a
P < 0.001 versus no treatment.
b
P > 0.05 versus no treatment.
c
P < 0.05 versus penicillin and P < 0.05 for levofloxacin at 20 versus levofloxacin at 40 mg/kg.