Table 4.
Genes associated with an increased risk of malignant arrhythmias and SCD in inherited cardiomyopathy.
| Inherited Cardiomyopathy | Genes Associated with SCD | Protein Encoded |
|---|---|---|
| DCM | TTN | Titin |
| LMNA | Lamin A/C | |
| FLNC | Filamin C | |
| SCN5A | Sodium voltage-gated channel alpha subunit 5 | |
| HCM | MYH7 | B-Myosin Heavy Chain 7 |
| MYBPC3 | Myosin-Binding Protein C 3 | |
| BrS | SCN5A | Nav1.5—Cardiac sodium channel α subunit |
| ARVD | PLN R14del | Phospholamban |
| LMNA | Lamin A/C | |
| SCN5A | Sodium voltage-gated channel alpha subunit 5 | |
| RBM20 | RNA binding motif protein 20 | |
| TMEM43 | Transmembrane Protein 43 | |
| LQTS | SCN5A | Nav1.5—Cardiac sodium channel α subunit |
SCD: sudden cardiac death; BrS: Brugada Syndrome; DCM: dilated cardiomyopathy; HCM: hypertrophic cardiomyopathy; LQTS: long QT syndrome; ARVD: arrhythmogenic ventricular dysplasia.