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Schematic representation of JAK/STAT signal transduction pathway by cytokines. A cytokine binding to the receptor induces JAK activation and, consequently, STAT phosphorylation. Activated STATs form hetero- or homodimers that translocate to the nucleus and regulate the transcription of genes that cause hyperinflammation and cytokine storm. Created with BioRender.com (accessed on 16 March 2022).
