Table 3.
Sequential changes in natriuretic peptides and adrenergic markers from baseline to 24 months after LAAC. (*—the result was statistically significant).
| Variable | Baseline | 24 h | 7 Days | 1 Month | 3 Months | 6 Months | 12 Months | 24 Months |
|---|---|---|---|---|---|---|---|---|
| NT-proANP, ng/mL | 9.94 (4.09–16.87) |
15.39 (10.93–16.10) * |
6.31 (3.71–11.79) * |
5.44 (4.29–10.58) * |
4.58 (4.00–5.48) * |
8.36 (5.10–14.80) |
9.03 (4.73–13.98) |
11.01 (4.98–19.81) |
| NT-proBNP, pg/mL | 167.8 (63.7–238.7) |
248.6 (101.3–331.2) |
189.9 (73.9–299.5) |
189.9 (79.8–225.4) |
154.3 (86.6–193.9) |
132.8 (72.4–189.2) |
123.2 (59.0–171.5) * |
100.9 (65.4–134.5) * |
| Adrenaline, pg/mL | 97.8 (52.8–120.0) |
67.0 (58.0–103.4) |
66.7 (50.1–82.4) |
56.0 (45.2–67.9) * |
53.5 (47.9–64.4) * |
53.4 (41.9–63.2) * |
60.0 (52.7–70.2) * |
52.0 (48.9–57.9) * |
| Noradrenaline, ng/mL | 584 (401–772) |
270 (94–398) * |
227 (163–548) * |
246 (188–518) * |
233 (188–282) * |
176 (150–208) * |
135 (97–253) * |
115 (89–193) * |
| Aldosterone, pg/mL | 165.6 (153.2–178.0) |
173.7 (151.9–186.6) |
163.9 (131.3–181.6) |
158.6 (153.2–195.3) |
159.2 (158.1–185.5) |
146.0 (130.3–142.7) * |
126.3 (105.0–148.9) * |
123.5 (114.9–130.2) * |
| Plasma renin activity, ng/mL/h | 1.63 (1.16–1.96) |
1.66 (1.25–1.99) |
1.29 (1.22–1.45) * |
1.30 (1.18–1.60) * |
1.19 (0.88–1.44) * |
1.25 (1.17–1.35) * |
1.12 (0.89–1.33) * |
1.21 (1.02–1.33) * |
| Vasopressin, pg/mL | 8.29 (6.26–13.86) |
6.97 (6.23–7.56) * |
3.44 (2.38–4.39) * |
3.05 (2.29–4.57) * |
4.26 (3.89–4.63) * |
2.87 (1.60–5.26) * |
2.85 (1.47–4.63) * |
2.79 (2.03–4.18) * |
| Endothelin-1, pg/mL | 1.98 (1.31–2.52) |
2.21 (1.92–2.61) * |
2.35 (1.52–2.80) * |
2.56 (1.94–3.14) * |
2.78 (1.85–3.32) * |
2.84 (2.05–3.80) * |
2.94 (2.44–3.01) * |
3.50 (2.89–4.05) * |